Symptoms for mpox are indistinguishable across all clades and may include:

• Skin rash often starting from the face before becoming generalised including involvement of palms and soles. However, presentation in the global outbreak of Clade II involves only a few or single localised lesions, especially in the genital and groin areas, which do not spread further.

• Fever

• Headache

• Backache

• Swollen lymph nodes

• Muscle ache

• General feeling of exhaustion or profound weakness

Symptoms usually appear within 21 days after being exposed to the virus. While asymptomatic and pre-symptomatic transmission are possible, a person is typically infectious from the onset of symptoms until the skin lesions have scabbed over.